Leonardo
But mans desire to understand himself and the world around him could not be stopped and men like Leonardo da Vinci pursued their studies in the hope of finding the answers. A brilliant painter, engineer, astronomer and botanist, Leonardo helped launch the Renaissance and a new age of scientific discovery in the face of ridicule from the ignorant and bigoted. Even the most seemingly innocuous studies had to be undertaken with discretion, as the watchful eye of the Inquisition was ever present. In fact, many of his notes were written out so they could only be read in a mirror.
Galileo
In the sixteenth century, Galileo dared to challenge long-held beliefs by publicly endorsing the Copernican theory that the Earth revolved around the sun and not the reverse. This was considered heresy by the still-active Inquisition.
Galileo was sentenced to an indefinite prison term by the Catholic church for his crime. Only when he subsequently renounced Copernican theory was he allowed to return to his villa where he lived out the remainder of his life under house arrest by authority of the Inquisition, a broken man.